Dabrafenib + Trametinib in Pediatric Glioma With BRAF V600 Mutations
In a phase 2 trial of 110 pediatric patients with low-grade glioma with BRAF V600 mutations, the combination of dabrafenib plus trametinib had significantly more responses, longer
In a phase 2 trial of 110 pediatric patients with low-grade glioma with BRAF V600 mutations, the combination of dabrafenib plus trametinib had significantly more responses, longer
In children younger than 5 years, receipt of 2 or 3 doses of wild-type BNT162b2 vaccine was associated with a reduced risk of emergency department
In a cohort study of children with acute sinusitis who were treated in ambulatory settings, the risk of treatment failure was similar among those treated
A threshold of 1.7 mg/kg of tetrahydrocannabinol (THC) in children younger than 6 years of age “may guide medical management and preventive regulations,” investigators conclude based
In 3 articles, the American Academy of Pediatrics summarizes recommendations of the Advisory Committee on Immunization Practices (ACIP) for the use of vaccines for the
The Childhood Cancer Data Initiative (CCDI), launched in 2019 at the National Cancer Institute, could provide a model for adults, authors write, “transforming both clinical
Administered to pregnant women before preterm birth at 30–34 weeks’ gestation, the survival of children free of cerebral palsy at 2 years was not improved,
In patients with an inadequate response or intolerance to standard therapy used for the management of juvenile idiopathic arthritis, baricitinib was efficacious with an acceptable
For the treatment of multisystem inflammatory syndrome in children (MIS-C), glucocorticoids and intravenous immunoglobulin (IVIG) decrease hospital length of stay (LOS) when given early in
Low rates of completion of multidose vaccine series are reported for U.S. children in an analysis of national data. With more than 1 in 6