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Obesity Management in Adults

“Comprehensive, evidence-based obesity treatment combines behavioral interventions, nutrition, physical activity, pharmacotherapy, and metabolic/bariatric procedures as appropriate for individual patients,” conclude authors of a review article. “Behavioral interventions can attain approximately 5% to 10% weight loss,…

Translating Vaccine Effectiveness to Acceptance

While awaiting the availability of next-generation influenza vaccines, clinicians have the task of convincing patients of the value of influenza immunization in a season with multiple respiratory viruses circulating, editorialists write. A method developed by…

Erdafitinib in Advanced or Metastatic Urothelial Carcinoma

In patients with metastatic urothelial carcinoma and FGFR alterations after previous immune checkpoint treatment, the pan–fibroblast growth factor receptor (FGFR) inhibitor erdafitinib significantly increased overall survival, compared with chemotherapy, researchers report. Erdafitinib is currently approved for the…

PNN JournalWatch — 11.27.23

New England Journal of Medicine: Osimertinib With or Without Chemotherapy in EGFR-Mutated Advanced NSCLC New England Journal of Medicine: Combination Therapy for EGFR-Mutated Lung Cancer [editorial] New England Journal of Medicine: Postmenopausal Osteoporosis Lancet: Efficacy and Safety…

Other Recent Stories

Coadministration of Influenza, COVID-19 Vaccines

Coadministration of the BNT162b2 BA.4/5 bivalent mRNA COVID-19 vaccine (BNT162b2-biv) and seasonal influenza vaccine (SIV) in the community setting produced similar effectiveness and outcomes as when

Pharmacotherapy for Alcohol Use Disorder

Oral naltrexone 50 mg/d and acamprosate should be first-line pharmacotherapies for alcohol use disorder, according to a systematic review and meta-analysis of randomized clinical trials

Lower Diabetes Risk After COVID-19 Vaccination

In a cohort study, unvaccinated people with COVID-19 had a 62% higher chance of developing new-onset diabetes mellitus (DM), while vaccinated individuals with breakthrough COVID-19

Edoxaban in Atrial High-Rate Episodes

The incidence of a primary outcome of a composite of cardiovascular death, stroke, or systemic embolism was not reduced by anticoagulation with edoxaban in patients

Lorundrostat for Uncontrolled Hypertension

Compared with placebo, the aldosterone synthase inhibitor lorundrostat lowered blood pressure among patients with uncontrolled hypertension in the TARGET-HTN trial, researchers report. “Blood pressure reduction

Risks and Benefits of Cannabis Use

Clinical evidence supports effectiveness of cannabis-based medicines in people with multiple sclerosis, chronic pain, and inflammatory bowel disease, and in palliative medicine, according to a

Donanemab in Early Symptomatic Alzheimer Disease

Clinical benefits were evident in patients with early symptomatic Alzheimer disease after 76 weeks of treatment with the amyloid-targeting monoclonal antibody donanemab, according to findings of

Global Burden of Diabetes Through 2050

Type 2 diabetes is a preventable disease, but unless trends change, more than 10% of the population in nearly half the world’s countries will have

Once-Weekly Insulin Icodec in Type 2 Diabetes

Compared with once-daily insulin glargine U100 (glargine) in patients with type 2 diabetes, once-weekly insulin icodec (icodec) showed similar improvements in glycemic control, with fewer

DOACs vs. LMWHs for Cancer-Associated Recurrent VTEs

In patients with cancer and venous thromboembolism (VTE) events, prophylaxis of recurrence with direct oral anticoagulants (DOACs) was noninferior to low-molecular-weight heparins (LMWHs), a study shows.

Hydrocortisone in Severe Community-Acquired Pneumonia

Compared with placebo, hydrocortisone reduced the 28-day mortality risk among critically ill patients with severe community-acquired pneumonia, according to results of the Community-Acquired Pneumonia: Evaluation

Images of Medication-Related Osteonecrosis of the Jaw

Radiographic, dermatological, and oral manifestations of medication-related osteonecrosis of the jaw are illustrated in an Images in Clinical Medicine feature: “Medication-related osteonecrosis of the jaw

COPD and New Use of Combination Inhalers

Among new users of combination medication inhalers for chronic obstructive pulmonary disease (COPD), those on long-acting muscarinic antagonists (LAMAs) with long-acting β-agonists (LABAs) had a

Spironolactone for Acne in Women

As an alternative to oral antibiotics, spironolactone improved outcomes at week 24 in women with persistent acne, a placebo-controlled study shows. The Spironolactone for Adult

Treating Asthma in the COVID-19 Era

The need for new therapies and adaptations in treating severe asthma with SARS-CoV-2 circulating and COVID-19 a common respiratory illness are discussed in a review

COVID-19 Treatment Guidelines Updated

The COVID-19 Treatment Guidelines Panel last week updated its COVID-19 treatment guidelines, adding sections on pregnancy and lactation, revising information on therapeutic management of nonhospitalized

Drug Treatment for Type 2 Diabetes

Findings of a network meta-analysis of drug treatments for type 2 diabetes “highlight the need for continuous assessment of scientific progress to introduce cutting edge

Antibiotics, ICIs, Survival & the Gut Microbiome

In a population-level study of older adults with cancer, exposure to fluoroquinolones and other antibiotics months before immune checkpoint inhibitor (ICI) treatment was associated with

Shorter Course for Tuberculosis Treatment

Initial treatment of rifampin-sensitive tuberculosis with an 8-week course of bedaquiline and linezolid was noninferior to a standard 24-week antitubercular regimen, according to the TRUNCATE-TB

Adjunctive Cariprazine for Major Depressive Disorder

The second-generation antipsychotic agent (SGA) cariprazine, a dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, was effective for reducing depressive symptoms in a trial of adults with

Etranacogene Dezaparvovec for Hemophilia B

A clinical trial of etranacogene dezaparvovec gene therapy demonstrates its superiority over prophylactic factor IX with respect to annualized bleeding rate, researchers report, with a

RSV Prefusion F Protein Vaccine in Older Adults

In an international, phase 3 trial of 24,966 older adults, a  single dose of an AS01E-adjuvanted respiratory syncytial virus (RSV) prefusion F protein–based candidate vaccine (RSVPreF3

2023 Adult Immunization Schedule

The CDC’s Advisory Committee on Immunization Practices provides consolidated, summarized information in its 2023 immunization schedule for adults aged 19 years or older, published in

Baxdrostat for Treatment-Resistant Hypertension

In the BrigHTN trial, patients with treatment-resistant hypertension had dose-related reductions in blood pressure when taking the aldosterone synthase inhibitor baxdrostat. “The reduction in blood

PBMs & the FTC

The implications of the Federal Trade Commission (FTC) investigation of pharmacy benefits managers (PBMs) remain to be seen, write the authors of a Viewpoint article

Bimekizumab for Psoriatic Arthritis

In a pair of phase 3 trials, bimekizumab — a monoclonal immunoglobulin G1 antibody that inhibits interleukin (IL)-17A and -17F — was superior to active

ADA’s 2023 Standards of Care in Diabetes

Among the changes and refinements in the 2023 Standards of Care in Diabetes are the addition of tirzepatide as a glucose-lowering option in obesity management,

Aspirin Use & Ovarian Cancer Risk

Frequent aspirin use “is associated with lower ovarian cancer risk regardless of the presence of most other ovarian cancer risk factors,” conclude authors of an

Melanoma Treatments & Mortality Rate Trends

Use of newer pharmacological therapies for melanoma — including dual immunotherapy such as ipilimumab-nivolumab — appears to be reducing the long-term melanoma mortality rate (MMR)

Oral Zinc for Treating COVID-19

In a study of ambulatory and hospitalized patients with COVID-19, oral zinc for 15 days decreased the 30-day death rate, lowered the intensive care unit

Pharmacotherapy of Hypertension

For the 116 million Americans and more than 1 billion people worldwide who have hypertension, cardiovascular disease is a leading cause of related morbidity and

Prevention and Treatment of Monkeypox

To curb the monkeypox epidemic in both endemic areas in Africa and elsewhere, the effectiveness of existing treatments, vaccines, and vaccination strategies needs to be

Influenza Vaccines During the 2010s

Despite “great advances in our ability to follow influenza occurrence and determine vaccine effectiveness (VE)” during the 2010–2020 decade, outcomes remain suboptimal for influenza vaccines,

Ruxolitinib Cream for Vitiligo

Compared with a placebo vehicle in a pair of phase 3 trials, topical application of the JAK inhibitor ruxolitinib improved pigmentation of vitiligo lesions while

Treatment of Myocarditis

Conventional treatment of patients with myocarditis begins with guideline-directed management of arrhythmias and heart failure. When specific causes can be identified, targeted therapy is indicated,

Allopurinol in Ischemic Heart Disease

In the ALL-HEART trial, the use of allopurinol or usual care produced similar outcomes in older adults with ischemic heart disease and no history of

Home Care for Bronchiolitis in Infants

Home oxygen therapy is a feasible option for infants with bronchiolitis, according to authors of a systematic review and meta-analysis. Studies conducted at both high

Management of Heart Failure

New guidelines for heart failure (HF) update recommendations for medical therapy across the spectrum of ejection fraction (EF) values. The 2022 American College of Cardiology/American