The U.S. Preventive Services Task Force provides an updated evidence report and issues recommendations supporting its 2017 advice against the use of hormone therapy for
In a large-scale comparison of direct oral anticoagulants (DOACs; visual abstract available) in routine clinical practice, apixaban had the lowest risk for gastrointestinal bleeding (GIB)
Compared with first doses of the mRNA COVID-19 vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), first doses of the ChAdOx1-S adenovirus vaccine (Oxford/AstraZeneca) had a 30%
Differences in risk of acute liver injury are evident among the incretin-based drugs in a population-based analysis of patients with type 2 diabetes. DPP-4 inhibitors
Patients can take antihypertensive agents at the time of day most convenient for them and that minimizes adverse effects, authors conclude based on a study
In a head-to-head comparison with rivaroxaban, apixaban provided a lower risk for ischemic stroke or systemic embolism and for bleeding in patients with atrial fibrillation
Whether opioids provide an acceptable risk–benefit balance when used for musculoskeletal pain at discharge from the emergency department (ED) is uncertain, conclude authors of a
Adverse events were limited and benefits continued when the PCSK9 inhibitor evolocumab was continued for more than 8 years in patients with established atherosclerotic cardiovascular
Used to treat people with hypertension, the thiazide-like agent chlorthalidone should be preferred over hydrochlorothiazide, according to the author of an opinion article. If the
On days when oxycodone was administered, paroxetine significantly reduced the ventilatory response to hypercapnia in a study of 25 healthy participants. Quetiapine did not have