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Duration of Antibiotic Therapy for Bacterial Meningitis in Young Infants

High-quality comparative effectiveness research is needed to answer the question of how long young infants need to receive parenteral antibiotic duration in bacterial meningitis, conclude authors of a systematic review.

Based on 1 randomized controlled trial, 25 cohort studies, and 6 case series, the authors report: “The randomized controlled trial found no difference in treatment failure rates between 10 and 14 days of therapy. One cohort study concluded that antibiotic courses >21 days were not associated with improved outcomes as compared with shorter courses. The remaining studies had small sample sizes and/or did not stratify outcomes by therapy duration. Meta-analysis was not possible because of the heterogeneity of the treatments and reported outcomes.”

Accompanying editorial available.

Source: Pediatrics